心筋障害と血中酸素分圧との関連におけるSympathomimetic Aminesの作用

概要

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We measured the blood oxygen tension (Po_2) in the rat aorta in connection with cardiac lesions caused by the subcutaneous administration of sympathomimetic amines. The degree of cardiac lesions caused by l-isoproterenol, which acts predominantly on the β-receptor, or dl-norepinephrine, which acts predominantly on the α-receptor, was dose dependent, and these drugs decreased the Po_2 in the same dose range. The decrease in Po_2 due to dl-norfenefrine, which causes very little cardiac lesion and acts on the α-receptor, was not significant. Moreover, it is ascertained that cardiac lesions and a decrease in Po_2 caused by l-isoproterenol could be prevented by pretreatment with propranolol and that cardiac lesions and a decrease in Po_2 caused by dl-norepinephrine could be prevented by pretreatment with phentolamine.
社団法人日本薬学会の論文
1981-02-25