脂質過酸化物による螢光物質の形成(第2報)

概要

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Tow stable secondary products derived from the autoxidation of methyl linolenate were separated by column and high performance liquid chromatographies. Each secondary product showed ultraviolet absorption spectrum at 230 nm and 250-260 nm, and reacted with 2,4-dinitrophenylhydrazine. However, secondary products treated with sodium borohydride resulted in the disappearance of ultraviolet absorption spectrum at 250-260 nm and reactivity with 2,4-dinitrophenylhydrazine. Each secondary product formed six fluorescent substances with stearylamine, and all these fluorescent substances showed excitation maxima at 350-360 nm and emission maxima at 420-430 nm. However, characterization of these fluorescent substances differed from those which formed from stearylamine or other amino compounds with malondialdehyde. These results suggest that secondary products had conjugated diene structure with aldehyde group and that several lipofuscin-like fluorescent substances would be formed by the reaction of various amino compounds with secondary product with aldehyde group.
社団法人日本薬学会の論文
1981-05-25