各種漢方方剤のウサギ血小板ホスホリパーゼA_2阻害効果及び高コレステロール血症ウサギの血小板凝集能亢進に対する当帰芍薬散の抑制効果

概要

論文の詳細を見る
The inhibitory mechanism of 6 traditional Chinese medicines on rabbit platelet aggregation in vitro, and the suppressive effect of oral administration of Toki-syakuyakusan on hyper-aggregability of the platelet from rabbit fed high cholesterol diet for 2 months, were investigated. Collagen-induced aggregation was inhibited by Keisi-bukuryogan, Kami-syoyo-san, Dai-saiko-to, Toki-syakuyaku-san, Hatimi-zio-gan and Syo-saiko-to in their lower concentrations than those inhibiting arachidonic acid- and thrombin-induced aggregation. These traditional Chinese medicines inhibited the release of [^3H] arachidonic acid from membrane phospholipids by phospholipase A_2,in [^3H] arachidonic acid-labelled platelets under stimulation with collagen and thrombin in the concentration ranges that inhibited each aggregation. In their higher concentrations to inhibit arachidonic acid-induced aggregation, they suppressed the conversion of arachidonic acid to thromboxane A_2 by about 50%. However, they had no effect on diacylglycerol formation induced by thrombin. The oral administration of Toki-syakuyaku-san depressed the increased aggregability of platelets from rabbit fed high cholesterol diet by 20-40% at the period of 1-2 months of feeding, without affecting plasma and platelet cholesterol level. These results indicate that the traditional Chinese medicines used here have an inhibitory effect on platelet phospholipase A_2 activation, rather than on cyclooxygenase, and therefore inhibit platelet activation in vitro and ex vivo.
公益社団法人日本薬学会の論文
1989-11-25

各種漢方方剤のウサギ血小板ホスホリパーゼA_2阻害効果及び高コレステロール血症ウサギの血小板凝集能亢進に対する当帰芍薬散の抑制効果

スポンサーリンク

概要

著者

関連論文

スポンサーリンク