血液細胞の細胞膜におけるリン脂質の動態と機能.両親媒性薬物の作用機構に関連して
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概要
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An asymmetric modification of the cell membrane lipid bilayer of erythrocytes by means of exogenous phospholipase (PL) treatment or of phospholipid addition induced an echinocyte- or stomatocyte-type shape change of the cells. Such membrane shape change was demonstrated to be due to asymmetric swelling or shrinkage of the lipid bilayer halves, from the simultaneous determination of the change or intra-bilayer transfer of the phospholipid molecules. In the collagen-induced activation of blood platelets, the importance of PLA_2 activation as the initial reaction of the signaling system was demonstrated, and the regulatory effects of the membrane fluidity change on the enzyme activation were also shown. In the antigen-induced activation of peritoneal mast cells, a pathway through the PLD activation appeared to be more important. Phosphatidic acid produced from the membrane phospholipids through the PLD activation was shown to act as an intracellular mediator to stimulate the PLA_2 activation. Various amphiphilic drugs, including benzylisoquinoline alkaloids such as cepharanthine, were shown to inhibit the platelet activation and the mechanism was studied. The anti-platelet activity appeared to be mainly due to inhibition of the PLA_2 activation.
- 公益社団法人日本薬学会の論文
- 1994-06-25
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関連論文
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- 血液細胞の細胞膜におけるリン脂質の動態と機能.両親媒性薬物の作用機構に関連して
- まるごとの細胞で膜を研究する者の繰り言(生体膜研究の展望)
- Disturbing Effect of Cationic Amphiphilic Drugs on Phospholipid Asymmetry of the Membrane Lipid Bilayer of Human Erythrocytes
- ヒト赤血球膜に対するペニシリンの作用
- 赤血球と血小板の細胞膜における膜リン脂質の多彩な役割 (血液細胞の細胞膜の研究における最近の進歩)
- 赤血球膜の構造と機能
- 赤血球と血小板の細胞膜における膜リン脂質の多彩な役割 (血液細胞の細胞膜の研究における最近の進歩)
- Characteristics of Human Erythrocytes with Artific Ally-Increased ATP and/or 2, 3-Diphosphoglycerate Contents
- Hyperlipidemia and Erythrocyte Shape Change
- タイトル無し
- Furlher Sludies on Enzymic Determination of Plasma Sphingomyelin:The Comparison with TLC Method
- Possible Adsorption of Aldolase and Glyceraldehyde-3-Phosphate Dehydrogenase into the Erythrocyte Ghosts Prepared Under a Hypotonic Condition
- Increase in the Activity of Rhizopus C-Lipase on Human Plasma Lipoproteins by Treatment with Phospholipid