亜硫酸水素ナトリウムに起因する注射液の配合変化に対するブドウ糖輸液の効果

概要

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Sodium bisulfite is often employed as an antioxidant in injections. However, residual bisulfite in some commercial preparations was largely responsible for the cleavage of fulsultiamine and thiamine in parenteral admixtures during storage. Results are presented on the rate of fulsultiamine cleavage by variation of the bisulfite concentration (0-4×10^<-4>M). Plots of the logarithm of percentage of residual fulsultiamine against time were linear and the cleavage was first-order with respect to fulsultiamine. It was also found that fulsultiamine and thiamine were stabilized by glucose in the admixture ; i.e., without the addition of glucose the degradation rate constant was 738M^<-1>h^<-1> for fulsultiamine and 33.8M^<-1>h^<-1>for thiamine in aqueous solution of pH 5.0 at 20℃, and by the addition of 50% glucose the rate constant decreased to 95M^<-1>h^<-1> for fulsultiamine and 4.5M^<-1>h^<-1> for thiamine, respectively.
社団法人日本薬学会の論文
1987-10-25