混注薬におけるpH依存性外観変化の予測法 : 第2報

概要

論文の詳細を見る
Following the previous study, the prediction method of incompatibility in the case of 2 kinds of injection in a single infusion was investigated by estimating the pH of the admixture solution. Data of the previous paper, such as pH characteristic curves (pH titration curves), positive or negative equivalent values (strength of acidity or alkalinity) and values of incompatible pH were also used in the present study. The pH of the admixture was determined on the pH characteristic curve of the injection having the most dominant buffer action, by plotting the sum of equivalent values for the other 2 preparations. The change in appearance of 2 injections in a single infusion was predicted by comparing the estimated pH of the admixture with the incompatible pH for each of injections. From the above results, it was confirmed that the incompatibility for the admixture of 3 preparations could also be predicted by using pH characteristic curves, equivalent values and values of incompatible pH for each injection.
日本医療薬学会の論文
1984-12-20