混注薬におけるpH依存性外観変化の予測法

概要

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It was investigated in order to predict the pH-dependent incompatibility (haze formation, precipitation etc.) of the injection in infusion solution. 3 kinds of injections diluted to 500ml with distilled water and 35 kinds of infusion solutions (500ml) were titrated with 0.1 N HCl and 0.1 N NaOH, respectively. Then the pH characteristic curve was defined as a continuous curve that consists of 2 kinds of pH titration curves (with 0.1 N HCl and 0.1N NaOH). Positive or negative equivalent values (that represent acidity or alkalinity) of the injection and infusion solutions were determined by using the pH characteristic curve. pH of the admixture was determined by using the pH characteristic curve in which the other equivalent value was plotted. The appearance change of injection in infusion solution was predicted by comparing the estimated pH and the incompatible pH of the admixture were determined preliminarily.
日本医療薬学会の論文
1983-10-20