Isosorbide Dinitrate に関する研究 (第1報) : キャピラリーカラムを用いたガスクロマトグラフィーによる Isosorbide Dinitrate の血中濃度測定法(分析化学)

概要

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A sensitive and accurate gas chromatographic method was developed for the determination of isosorbide dinitrate (ISDN) in the human plasma. ISDN was extracted from the plasma with n-hexane in alkaline conditions and analysed by gas chromatography with an electron capture detector. As ISDN has high adsorptive activity on glass, fused silica capillary column with low surface-activity was used for the separation of ISDN. Isomannide dinitrate was used as an internal standard. This procedure provided a linear calibration curve ranging 0.25 to 16.0 ng of ISDN/ml of the plasma. The lower limit of detection for ISDN was 0.1 ng/ml of plasma. This method may be used more widely for the clinical pharmacokinetic study and bioavailability study of ISDN.
社団法人日本薬学会の論文
1986-11-25