有機リン系殺虫剤由来の酸性リン酸エステル類のラットにおける代謝と毒性

概要

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Metabolism and toxicity of acid phosphate esters were studied in the rat. Diethyl phosphate (DEP), diethyl thiophosphate (DETP) and diisopropyl phosphate (DIPP) were administered to rats at a dose of 1 g/kg. DEP-applied rats excreted inorganic phosphate and organic phosphate in the 24 h urine at amounts of 53% and 13%, of the dose respectively. DETP-treated rats excreted inorganic phosphate and organic phosphate in their urine at amounts of 18% and 10%, of the dose respectively. DIPP-treated rats excreted inorganic phosphate and organic phosphate in their urine at amounts of 8% and 9%, of the dose respectively. The DETP-treated rats showed symptoms such as salivation, lacrimation and tremors. DETP intensely inhibited cholinesterase in rat brain homogenate, and DEP weakly inhibited the cholinesterase activity. On the other hand, DIPP did not inhibit the cholinesterase activity. The inhibition of cholinesterase induced by DETP was higher than that of diazinon.
社団法人日本薬学会の論文
1993-12-31