Studies on the Constituents of the Seeds of Hernandia ovigera L. VIII. Syntheses of (±)-Desoxypodophyllotoxin and (±)-β-Peltatin-A Methyl Ether
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概要
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(±)-Desoxypodophyllotoxin (2), a chief component of the seeds of Hernandia ovigera L., and (±)-β-peltatin-A methyl ether (3), an analogous phenyltetralin lignan, which have 2,3-trans, 3,4-cis configuration were synthesized according to the method developed for the synthesis of hernandin (1). The syntheses were pursued using the corresponding 4-phenyl-1,2-dihydronaphthalene lactones (9 and 10) followed by cleavage of the lactone moiety to give the unsaturated hydroxy acids (11 and 12). Subsequent hydrogenation and ring closure by means of p-toluenesulfonic acid afforded both 2,3-trans, 3,4-cis and 2,3-cis, 3,4-cis ligans (2 and 13 or 3 and 14), which were isolated by preparative thin layer chromatography.
- 公益社団法人日本薬学会の論文
- 1991-01-25
著者
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山口 秀夫
Osaka University of Pharmaceutical Sciences
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有本 正生
Osaka College of Pharmacy
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有本 正生
大阪薬大
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加島 竜彦
Osaka University of Pharmaceutical Sciences
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田ノ口 真理子
Osaka University of Pharmaceutical Sciences
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田之口 真理子
Osaka University Of Pharmaceutical Sciences
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有本 正生
Osaka University Of Pharmaceutical Sciences
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