Studies on the Constituents of the Seeds of Hernandia ovigera L. V. : Syntheses of Epipodophyllotoxin and Podophyllotoxin from Desoxypodophyllotoxin
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概要
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Epipodophyllotoxin (EPT) and podophyllotoxin (PT) were prepared from desoxypodophyllotoxin (DPT), obtained from the seeds of Hernandia ovigera L. (Hernandiaceae) EPT was obtaind together with dehydrodesoxypodophyllotoxin (I) by a radical bromination of DPT with N-bromosuccinimide (NBS) followed by hydrolysis of the resultant 1-bromo-DPT, which was confirmed to be a mixture of 1α- and 1β-bromo compounds (7 : 3). EPT was oxidized with pyridinium chlorochromate to give podophyllotoxone (IV). The stereoselective reduction of IV to afford PT was examined with a variety of reagents, and borane-tert-butylamine complex was found to be effective.
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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山口 秀夫
Osaka University of Pharmaceutical Sciences
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中島 淳二
Osaka College of Pharmacy
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有本 正生
Osaka College of Pharmacy
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有本 正生
大阪薬大
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田之口 眞理子
Osaka University of Pharmaceutical Sciences
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深田 能成
Osaka Collge of Pharmacy
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田之口 真理子
Osaka University Of Pharmaceutical Sciences
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有本 正生
Osaka University Of Pharmaceutical Sciences
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