Luminol Chemiluminescence and Peroxidation of Unsaturated Fatty Acid Induced by the Xanthine Oxidase System : Effect of Oxygen Radical Scavengers
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概要
- 論文の詳細を見る
Addition of luminol to the xanthine oxidase system caused the production of chemiluminescence (CL). Superoxide dismutase (SOD) and singlet oxygen (^1O_2) scavengers inhibited the CL, whereas catalase and hydroxyl radical (HO) scavengers had no significant effect, suggesting that ^1O_2 species derived from O^-_2 is responsible for the light emission of luminol. Addition of unsaturated acids to the xanthine oxidase system in the presence of luminol resulted in quenching of CL, and peroxidation of the unsaturated fatty acids was observed. SOD and ^1O_2 scavengers also inhibited the peroxidation of arachidonate, indicating that ^1O_2 generated in the xanthine oxidase system participates in the peroxidation reaction.
- 公益社団法人日本薬学会の論文
- 1985-08-25
著者
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小木曽 健人
Hokkaido Institute Of Pharmaceutical Sciences
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三浦 俊明
Hokkaido Institute of Pharmaceutical Sciences
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三浦 俊明
北海道薬科大学
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Ogiso T
Hokkaido Institute Of Pharmaceutical Sciences
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