Denaturation of Erythrocytes by Exposure to photochemically Produced Superoxide Radicals
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概要
- 論文の詳細を見る
Rat erythrocytes were incubated in the photoactivated riboflavin system, in which the formation of erythrocytes resistant to hypotonic hemolysis occured. Cells illuminated for 60 min were as sensitive to hypotonic hemolysis as unilluminated cells. In contrast, cells illuminated for 120 min showed complete resistance to hypotonic hemolysis. Experiments with catalase, superoxide dismutase and other radical scavengers showed that the formation of protected cells appears to be due to H_2O_2 generated in the photoactivated riboflavin system. Microscopic examination revealed that cells exposed to O_2-for 120 min were enlarged and contained more intensely intracellular materials around the interior periphery. These results suggest that rigid cells resistant to hypotonic hemolysis may be formed by H_2O_2 oxidation of hemoglobin and membrane elements of the cells.
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
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小木曽 健人
Hokkaido Institute Of Pharmaceutical Sciences
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三浦 俊明
Hokkaido Institute of Pharmaceutical Sciences
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三浦 俊明
北海道薬科大学
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Ogiso T
Hokkaido Institute Of Pharmaceutical Sciences
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