Lipid Peroxidation of the Erythrocyte Membrane Caused by Stimulated Polymorphonuclear Leukocytes in teh Presence of Ferritin
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概要
- 論文の詳細を見る
Lipid peroxidation of erythrocyte membrane was caused by phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMN) in the presence of ferritin. PMN themselves were not peroxidized. A lag period was observed before the start of the peroxidation reaction. In contrast, ferritin iron was continuously released by PMA-stimulated PMN, suggesting that accumulation of free iron in the reaction system was importnat for processing of the peroxidation reaction. Superoxide dismutase, catalase, hydroxy radical scavengers and an iron chelator, diethylenetriaminepenta-acetic acid, inhibited the lipid peroxidation, indicating that the lipid peroxidation is initiated by a hydroxyl radical generated from the interaction of H_2O_2 with ferrous iron released from ferritin.
- 公益社団法人日本薬学会の論文
- 1991-06-25
著者
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三浦 俊明
Department of Biochemistry, Hokkaido Institute of Pharmaceutical Sciences
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三浦 俊明
北海道薬科大学
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小木曾 健人
Department of Biochemistry, Hokkaido Institute of Pharmaceutical Sciences
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小木曾 健人
Department Of Biochemistry Hokkaido Institute Of Pharmaceutical Sciences
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