Synthesis and Biological Evaluation of Ebselen and Its Acyclic Derivatives
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概要
- 論文の詳細を見る
Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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Hsu Wen
Cancer Medical Center And Department Of Radiation Oncology Buddhist Tzu Chi Medical Center
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HSU Ling-Yih
School of Pharmacy, National Defense Medical Center
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HWANG Jing-Min
Department of Radiation Oncology, National Defense Medical Center
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Chang Tsu
Department Of Biochemistry National Defense Medical Center
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Hsu Ling-yih
Department Of Biological Science And Technology China Institute Of Technology
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Hsu Ling
School Of Pharmacy
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Hsu Ling-yih
School Of Pharmacy National Defense Medical Center
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Hwang Jing-min
Department Of Radiation Oncology Tri-service General Hospital
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Huang Mei-lan
School Of Pharmacy National Defense Medical Center
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CHANG Tsu-Chung
Department of Biochemistry, National Defense Medical Center
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HSU Wen-Lin
Cancer Medical Center and Department of Radiation Oncology, Buddhist Tzu Chi Medical Center
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