Synthesis and Biological Evaluation of Sulfur-Containing Cinnamate and Salicylate Derivatives

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概要

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• UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2,2'-dithiocinnamate derivatives and 2,2'-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological activities of the synthesized compounds were assayed for ABTS [2,2'-azinobis-(3-ethyl-benzo-thiazoline-6-sulfonic acid)] radical scavenging activity, MMP-1 inhibitory activity, and cytotoxicity to human dermal fibroblast cells. Compounds with potential of resistance to UV irradiation were identified. These compounds are expected to be useful for preventing photo-damage to the skin.

• 2008-03-01

著者

• CHIANG Chih-Chia

  Department of Applied Chemistry, Chung Cheng Institute of Technology

• TSAI Hou-Jen

  Department of Applied Chemistry, Chung Cheng Institute of Technology

• Chiang Chih

  Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive

• Chang Tsu

  Department Of Biochemistry National Defense Medical Center

• Tsai Hou

  Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive

• Hsu Ling-yih

  Department Of Biological Science And Technology China Institute Of Technology

• Hsu Ling

  School Of Pharmacy

• CHANG Tsu-Chung

  Department of Biochemistry, National Defense Medical Center

• Chiang Chih-Chia

  Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University

• Tsai Hou-Jen

  Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University

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