Synthesis of Selenium-Containing Polyphenolic Acid Esters and Evaluation of Their Effects on Antioxidation and 5-Lipoxygenase Inhibition
スポンサーリンク
概要
- 論文の詳細を見る
Six novel selenium-containing polyphenolic acid esters were synthesized and evaluated as antioxidants and 5-lipoxygenase inhibitors. Synthesis of the title compounds involved the Mitsunobu reaction of polyphenolic acids (4-8, 14) with 2-phenylselenoethanol (3). Compounds 22, 23, and 25 were found to be very effective antioxidants and 5-lipoxygenase inhibitors with activity comparable to or better than caffeic acid (3, 4-dihydroxycinnamic acid) phenethyl ester (CAPE).
- 公益社団法人日本薬学会の論文
- 2005-11-01
著者
-
CHIANG Chih-Chia
Department of Applied Chemistry, Chung Cheng Institute of Technology
-
Chiang Chih
Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive
-
Chang Tsu
Department Of Biochemistry National Defense Medical Center
-
Tsai Hou
Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive
-
Hsu Ling-yih
Department Of Biological Science And Technology China Institute Of Technology
-
Hsu Ling
School Of Pharmacy
-
Lin Chi-fu
School Of Pharmacy National Defense Medical Center
-
Lin Chi
School Of Pharmacy National Defense Medical Center
-
CHANG Tsu-Chung
Department of Biochemistry, National Defense Medical Center
-
Chiang Chih-Chia
Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University
関連論文
- HIV-1 Integrase Inhibition of Biscoumarin Analogues
- Synthesis and Biological Evaluation of Sulfur-Containing Cinnamate and Salicylate Derivatives
- Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues
- Synthesis of Selenium-Containing Polyphenolic Acid Esters and Evaluation of Their Effects on Antioxidation and 5-Lipoxygenase Inhibition
- Evaluation of Polyphenolic Acid Esters as Potential Antioxidants(Medicinal Chemistry)
- Synthesis and Biological Evaluation of Ebselen and Its Acyclic Derivatives
- Synthesis and Biological Activity of Sulfur-Containing Aryl-aldehyde Schiff Bases
- Radio Frequency Power Performance Enhancement for Asymmetric Lightly Doped Drain Metal–Oxide–Semiconductor Field-Effect Transistors on SiC Substrate
- A Clustering K-Anonymity Scheme for Location Privacy Preservation
- Improved Radio Frequency Power Characteristics of Complementary Metal–Oxide–Semiconductor-Compatible Asymmetric-Lightly-Doped-Drain Metal–Oxide–Semiconductor Transistor
- Synthesis and Protective Effects of Bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts