Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues

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概要

• 論文の詳細を見る

• Present studies were undertaken on the preparation of synthetic analogues of bis- or tetra-coumarins and their activity against HIV-1 integrase (HIV-1 IN). Among these coumarin analogues, compounds 14, 16 and 18 were found to be potent molecules against HIV-1 IN at IC_<50> values of 0.96, 0.58, and 0.49 μM, respectively. The results provided a tool for guiding the further design of more potent antiviral agents and for predicting the affinity of related compounds.

• 公益社団法人日本薬学会の論文
• 2007-12-01

著者

• CHIANG Chih-Chia

  Department of Applied Chemistry, Chung Cheng Institute of Technology

• TSAI Hou-Jen

  Department of Applied Chemistry, Chung Cheng Institute of Technology

• Chiang Chih

  Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive

• Tsai Hou

  Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive

• Hsu Ling-yih

  Department Of Biological Science And Technology China Institute Of Technology

• Hsu Ling

  School Of Pharmacy

• Lin Chi-fu

  School Of Pharmacy National Defense Medical Center

• MOUSCADET Jean-Francois

  LBPA, CNRS, Ecole Normale Superieure de Cachan

• LIU Chi-Tsan

  School of Pharmacy, National Defense Medical Center

• Liu Chi-tsan

  School Of Pharmacy National Defense Medical Center

• Lin Chi

  School Of Pharmacy National Defense Medical Center

• Mouscadet Jean-francois

  Lbpa Cnrs Ecole Normale Superieure De Cachan

• Chiang Chih-Chia

  Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University

• Tsai Hou-Jen

  Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University

関連論文

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• Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues
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