Evaluation of Polyphenolic Acid Esters as Potential Antioxidants(Medicinal Chemistry)
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概要
- 論文の詳細を見る
Six polyphenolic acid esters were synthesized and their antioxidative properties were evaluated in three model systems [2,2′-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, 2,2′-azobis(2-amidinopropane)dihydrochloride (AAPH)-induced lipid peroxidation system, and the dye-bleaching assay of peroxynitrite radical]. Among these compounds, we found that compounds 4 [3,4-dihydroxy-benzoic acid-(2-phenoxyethyl ester)], and 5 [3,4-dihydroxy-cinnamic acid-(2-phenoxyethyl ester)] provided comparable activity to caffeic acid phenethyl ester (CAPE) in the DPPH model. Compound 3 [2,5-dihydroxy-benzoic acid-(2-phenoxyethyl ester)], was found to be more active than CAPE in the AAPH system, it also displayed about 2-fold greater activity than CAPE in the peroxynitrite radical model. These results suggest that these phenolic acid ester derivatives, with their potent anti-oxidant activities, may have useful applications as antioxidants.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
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Hsu Wen
Cancer Medical Center And Department Of Radiation Oncology Buddhist Tzu Chi Medical Center
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Chang Tsu
Department Of Biochemistry National Defense Medical Center
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Hsu Ling-yih
Department Of Biological Science And Technology China Institute Of Technology
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Hsu Ling
School Of Pharmacy
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Hsu Ling-yih
School Of Pharmacy National Defense Medical Center
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Lin Chi-fu
School Of Pharmacy National Defense Medical Center
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Lin Chi
School Of Pharmacy National Defense Medical Center
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HSU Wen
School of Pharmacy, Pharmaceutical Research Institute
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Hsu Wen-Chuan
School of Pharmacy, Pharmaceutical Research Institute
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