HIV-1 Integrase Inhibition of Biscoumarin Analogues
スポンサーリンク
概要
- 論文の詳細を見る
Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents.
- 社団法人日本薬学会の論文
- 2006-05-01
著者
-
Su Chang-xiao
School Of Pharmacy National Defense Medical Center
-
MOUSCADET Jean-Francois
L.B.P.A, CNRS UMR8532, Ecole Normale Superieure de Cachan
-
CHIANG Chih-Chia
Department of Applied Chemistry, Chung Cheng Institute of Technology
-
TSAI Hou-Jen
Department of Applied Chemistry, Chung Cheng Institute of Technology
-
HSU Ling-Yih
School of Pharmacy, National Defense Medical Center
-
Chiang Chih
Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive
-
Tsai Hou
Department Of Applied Chemistry And Materials Science Institute Of Technology National Defense Unive
-
Hsu Ling-yih
Department Of Biological Science And Technology China Institute Of Technology
-
Hsu Ling
School Of Pharmacy
-
Hsu Ling-yih
School Of Pharmacy National Defense Medical Center
-
MOUSCADET Jean-Francois
LBPA, CNRS, Ecole Normale Superieure de Cachan
-
Mouscadet Jean-francois
Lbpa Cnrs Ecole Normale Superieure De Cachan
-
Chiang Chih-Chia
Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University
-
Tsai Hou-Jen
Department of Applied Chemistry and Materials Science, Institute of Technology, National Defense University
-
Mouscadet Jean-Francois
L.B.P.A CNRS UMR8532, Ecole Normale Superieure de Cachan
関連論文
- HIV-1 Integrase Inhibition of Biscoumarin Analogues
- Synthesis and Biological Evaluation of Sulfur-Containing Cinnamate and Salicylate Derivatives
- Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues
- Synthesis of Selenium-Containing Polyphenolic Acid Esters and Evaluation of Their Effects on Antioxidation and 5-Lipoxygenase Inhibition
- Evaluation of Polyphenolic Acid Esters as Potential Antioxidants(Medicinal Chemistry)
- Synthesis and Biological Evaluation of Ebselen and Its Acyclic Derivatives
- Synthesis and Biological Activity of Sulfur-Containing Aryl-aldehyde Schiff Bases
- A New Synthetic Route towards the Mono-O-protected Anticonformationally Constrained Pyrimidine Acyclic Nucleoside
- Chemical Modification of Coumarin Dimer and HIV-1 Integrase Inhibitory Activity
- Synthesis and Protective Effects of Bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts