アルツハイマー病とアルコール痴呆の事象関連電位

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We investigated event-related potential(P300)in two types of demented patients.Twelve patients with Altzheimer's disease(AD),11 with alcohol associated dementia(AAD)and 28 normal controls participated in this study.We measured the latencies of N100 and P300 at Pz and Cz after odd-ball paradigm.N100 peaks at Pz and Cz were within the normal range in all patients.However,P300 peaks at Pz and Cz were significantly delayed in all demented patients.There were no statistical differences in the latencies of P300 in each demented group.P300 latencies at Cz and Pz were found to be negatively correlated with Hasegawa's dementia scale.These results suggest that demented illness has the same influence on the P300 latency regardless of the cause of dementia and P300 may be a useful means to assess the degree of dementia.アルツハイマー病およびアルコール痴呆の事象関連電位（P300）の検討を行ったところ，N100潜時は両群とも統制群と有意な差異は認められなかったが，P300潜時は延長していた。痴呆の程度がほぼ同じ場合，アルツハイマー病とアルコール痴呆の間にはP300潜時の差は認められなかった。また，P300潜時と長谷川式痴呆尺度の間には相関が認められ，P300潜時は痴呆の他覚的指標として有用と考えられた。
大阪教育大学の論文