潰瘍性大腸炎に対する白血球系細胞除去療法

概要

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Leukocytapheresis (LCAP) with leukocyte removal filter and granulocytapheresis (GCAP) with G-1 column were performed on patients with ulcerative colitis (UC). We assessed the effect and safety of prednisolne (PSL), LCAP, and GCAP therapies. According to the severity and condition of the disease, the control committee for these therapies separated the patients equally into 4 groups : namely LCAP group : its drug therapy group, called LCAP-D : GCAP group : and its drug therapy group, GCAP-D. Drug therapy groups were separately made for the LCAP and GCAP groups. During intensive therapy, 69.7% of the patients achieved improvement by LCAP and 71.4% by GCAP, however, only 34.6% of the patients achieved improvement by LCAP-D and 40.6% by the GCAP-D. The adverse effect incidence was about 25% in the LCAP and GCAP groups and 45- 58% in the drug therapy groups. Thus, additional LCAP or GCAP to UC drug therapy is shown to be a more effective and safer intensive UC therapy than high-dose steroid therapy and increasing dosage. Please refer to J Gastroenterology for more detailed results.
日本アフェレシス学会の論文
1999-02-28