潰瘍性大腸炎治療における顆粒球吸着療法の有効性メカニズムについて(接着分子,Mac-1とLECAM-1の変動より) : ビーズを用いた白血球系細胞除去療法

概要

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We examined adhesion molecule expressions on peripheral granulocytes from patients with ulcerative colitis who are being treated by monocyte-granulocytapheresis (M-GCAP) for the prospective multicenter trial of M-GCAP in our institution. LECAM-1 expression on granulocyte surface showed high before passing G-1 column ; however, it decreased significantly (ρ<0.01) after passing through the column in most patients. However, we unexpectedly found that CD-11 b (Mac-1) increased significantly after passing through the column previously compared to in most patients. Thus the mechanism of M-GCAP antiinflammatory effect is not only decreasing the number of monocytes and granulocytes, but also the inhibition of adhesion molecule associated with rolling. which is the first process of infiltrating to inflamed tissue for leukocytes.
日本アフェレシス学会の論文
2000-02-29