Cryofiltrationが有効であった白血球除去療法抵抗性重症潰瘍性大腸炎の一例 : 血漿分画器(二重膜)を用いた治療

概要

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A 48-year-old woman was admitted to our hospital with recurrent severe ulcerative colitis (UC). She had been administered 60 mg/day of intravenous prednisolone, as well as intravenous hyperalimentation, with no improvement. On admission, the WBC count was within normal limits, but CRP and ESR were high. Colonoscopy (CF) suggested a bleeding ulcer. erosion, and necrotic tissue on the colonic mucosa. She was diagnosed as having severe UC. Although she had received steroid therapy and four sessions of leukocytapheresis, her condition was not improved ; CF suggested a UC active stage and no improvememt. The LCAP therapy appeared to be ineffective. We performed cryofiltration on the LCAP-resistant patient with UC. This therapy was performed once weekly for 8 weeks. Bloody stool disappeared after the 8th cryofiltration session. and the finding of CF examination also showed remission. These results suggest cryofiltration can be an effective therapy for UC and may be tried when LCAP therapy proves ineffective.
日本アフェレシス学会の論文
2000-02-29