潰瘍性大腸炎に対する体外循環治療における赤血球損失率の検討 : 白血球系細胞除去療法に関する有害事象

概要

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Extracorporeal circulation therapy (ECCT) has begun to be widely performed as a way to treat patients with ulcerative colitis (UC) and Crohn's; disease. ECCT has fewer side effects, but some suspect it might initiate clinical anemia in patients, since blood is filtrated by artificial materials. In this paper, these authors evaluated the loss rate of red blood cells (LRBC) in UC patients during ECCTs, such as leukocytapheresis with leukocyte removal filter (LCAP). granulocytapheresis (GCAP) with G-1 column, and leukocytapheresis with centrifugal system. LRBC was measured by the free-hemoglobin level remaining in the ECCT circuit after each session. The results were then defined into a percentage of LRBC per session of ECCT. In LCAP sessions, the average of the percentage in 7 UC patients was 0.38±0.16% (approx. 16-17 ml of blood loss from 60 kg patient). The same evaluation was performed with GCAP and leukocytapheresis with centrifugal system. These results prove that ECCT is not a maior risk of patient's anemia ; however, it is important to pay enough attention for blood loss during ECCT. A guideline for the safe administration of ECCT is proposed in this paper.
日本アフェレシス学会の論文
2000-02-29