潰瘍性大腸炎からの大腸癌発生対策としてのアフェレシス(<特集>がん疾患とアフェレシス)

概要

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Introduction: Colitic cancer (CC) associated with ulcerative colitis (UC) is a severe complication. In the present paper, we have reported the long-term effectiveness of the clinical backgrounds of non-operated and operated UC patients in order to evaluate the potential of Cytapheresis (CAP) for cancer prevention. Methods and Results: 70.2% of active steroid refractory UC patients treated with CAP had clinical remission induced. In addition, 12.5% of them could be expected to avoid relapse 3 years after finishing CAP. From 1984 to 2008, 1,066 UC patients have had their colons removed in our surgical department, and 2.1% of them had CC complications. The ratio for complicating CC was significantly lower in that of patients operated on after CAP (p<0.01). Discussion: The remission induction and 3 years non-relapsing ratios were similar to that of iv cyclosporine, which is a major strategy for severe UC in western countries. CAP has been suggested to settle the activity of steroid refractory flare of UC safely. And, this could prevent a potential risk of CC, which should be induced from long-term and severe UC inflammation.
日本アフェレシス学会の論文
2009-05-31