FINE STRUCTURAL STUDY OF ACID PHOSPHATASE ACTIVITY IN THE KUPFFER CELLS OF ANEMIC MICE

概要

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Ultrastructural findings of Kupffer cells, particularly with relation to acid phosphatase (ACPase) activity and erythrophagocytosis, are described in mice with hereditary erythroblastic anemia which showed symptoms of severe anemia during the postnatal period. At the 10th day after birth, the Kupffer cells of the anemic mice were swollen and intercalated the cytoplasmic process between the parenchymal cells. The lysosomes were more abundant than normal. In older mice, more progressed symptoms of erythroblastic anemia and more developed Kupffer cells were observed. At the 17th day, the secondary lysosomes and phagosomes with marked ACPase activity had dominated over the primary lysosomes. Some lysosomes release hydrolytic enzymes, including ACPase, into the cytoplasm of the Kupffer cell and the space of Disse and sinusoid.
日本組織細胞化学会の論文