Localization of p21/waf-1/cip-1 mRNA at the Terminal Differentiated Stage in Rat Dental Tissues
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概要
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The purpose of the present study was to investigate the expression pattern of p21/waf1/cip-1 mRNA on developing and adult oral tissues in rats. The paraffin sections were obtained from the lower and upper jaws of 18-day rat fetuses and of 2-month-old Sprague-Dawley rats. ln order to observe the expression pattern of the p2 Ilwaf- 1/cip-1 mRNA on the tissue sections, the in situ hybridization method was carried out. In the fetal oral tissues, dental papilla next to the internal dental epithelium, and preodontoblasts expressed the mRNA. In the adult oral tissues, the localization of p21/waf-1/cip-1 mRNA was observed in the suprabasal, spinous and granular layers of the oral epithelium. The late maturation stage of ameloblasts in the incisor, the osteoblasts, and the cementoblasts and the fibroblast-like cells of the acellular cementum-side in the periodontal ligamant also expressed the mRNA. These results indicated that pill waf-1/cip-1 mRNA was expressed at the area of the terminal differentiation in the dental tissues.
- 日本組織細胞化学会の論文
著者
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Sato Masaaki
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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SAITOH Masato
Department of Dental Science, Institute of Personalized Medical Science, Health Sciences University
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ABIKO Yoshihiro
Department of Dental Science, Institute of Personalized Medical Science, Health Sciences University
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NISHIMURA Michiko
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido
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KAKU Tohru
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido
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Mitamura Jiro
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido
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Arai Jiro
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido
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Kawakami Toshiyuki
Department Of Oral Health Science Graduate School Of Dental Medicine Hokkaido University
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Saitoh Masato
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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Kaku T
Department Of Oral Pathology School Of Dentistry Health Sciences University Of Hokkaido
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Mitamura Jiro
Department Of Oral Pathology School Of Dentistry Health Sciences University Of Hokkaido
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Nishimura Michiko
Division Of Clinical Oral Pathology Department Of Human Biology And Pathophysiology School Of Dentis
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Nishimura Michiko
Department Of Behavioral Pediatric Dentistry Graduate School Of Medicine And Dentistry Okayama Unive
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Nishimura Michiko
Department Of Oral Pathology School Of Dentistry Health Sciences University Of Hokkaido
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Arai Jiro
Department Of Oral Pathology School Of Dentistry Health Sciences University Of Hokkaido
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Kaku Tohru
Department Of Human Biology And Pathophysiology School Of Dentistry Health Sciences University Of Ho
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Abiko Yoshihiro
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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Abiko Yoshihiro
北海道医療大学･個体差医療科学センター 歯学部門
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Kaku Tohru
Deparment Of Oral Pathology School Of Dentistry Health Sciences University Of Hokkaido
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