放射性沃度造影剤 (Diodrast-I^<131>) を利用した腎機能検査法 (Radioactive Diodrast Renogram) の研究

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From the experience of treating 21 bladder tumor, which are in different grades and the stages, with intracavitary irradiation by using Co^<60> (Solution, suspension, and beads) following. conclusions were obtained. 1. Intracavitary irradiation is very effective to the tumor situated at the bladder neck and prostatic urethra. 2. Bladder tumor situated at the posterior or the lateral wall is difficult to beam homogeneously with intracavitary irradiation. To these tumors partial resection of the bladder followed with post-operative intracavitary irradition or external irradiation combining with intracavitary irradiation appear to be the method of choice. 3. Intracavitary irradiation is not able to prevent recurrence of vesical papillomatosis. 4. Intracavitary irradiation with the dose less than 10,000 r do not produce severe cystitis or atrophic bladder. As the other complication, mild irritable symptom of the rectum was observed in 30% of the cases. The experimental intracavitary irradiation was performed on 17 mongrel dogs under cystostomy and the radiation effects were studied by the histological examination. 1. Immediately after irradiation with dose of 5,000 r, mucous membranes were well-preserved, while capillaries in the submucous layer were dilated and markedly increased. In case of 8,000 r, most of the epithelial lining cells were desquamated. 2. The group which received the dose of 8,000 r showed incomplete regeneration of the epithelium four months after the irradiation. But the cases which were given predonisolone with the irradiation in this group showed remarkable regeneration, which is consistent with the appearance of the non-irradiated controles of one month after the surgery. 3. The intracavitary irradiation caused milder degeneration of the muscle layer than the cases which received the same dosage by the external irradiation. The intracavitary irradiation used as the supplemental treatment with anti-androgenic hormon therapy for 6 cases of the prostatic caecer showed favorable outcome.
社団法人日本泌尿器科学会の論文

放射性沃度造影剤 (Diodrast-I^<131>) を利用した腎機能検査法 (Radioactive Diodrast Renogram) の研究

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