下部尿路の尿流動態研究 : V. Alpha adrenergic blockerによる神経因性膀胱機能障害の治療

概要

論文の詳細を見る
The response of the lower urinary tract to alpha adrenergic blocker was studied. The contractile strength of detrusor muscle remained unchanged, while static urethral resistance and stimulated dynamic urethral resistance were decreased in response to intravenous administration of alpha adrenergic blocker, which were demonstrated in male and female dogs in vivo. A series of 37 patients (24 males and 13 females) with varying degrees of neurogenic bladder dysfunction were evaluated by oral administration of phenoxybenzamine hydrochloride, alpha adrenergic blocker. 6 patients were suffering from complete supranuclear lesion, 5 incomplete supranuclear lesion, 7 complete and 19 incomplete nuclear and/or infranuclear lesion. Effective daily dose of phenoxybenzamine was found between 5 and 15 mg a day, which was safe and tolerable for the majority of patients. 19 patients were treated with phenoxybenzamine, one of which had parasympathomimetics also. The rest required the combination therapy of phenoxybenzamine and intermittent self-catheterization. Objective improvement was always preceded by an improvement of subjective complaints, which was observed in 88% of patients and generally appeared in 12 to 48 hours. The significant decrease of residual urine was noted in 52% of patients. 7 patients with indwelling catheter were all liberated from it after the treatment. The maximum urethral pressure in the urethral pressure profilometry significantly decreased in 8 out of 11cases (73%), and 60% of patients showed an improved uroflowmetrogram. 43% of the cases complained of side effects such as dizziness, nasal obstruction and orthostatic hypotension.
社団法人日本泌尿器科学会の論文
1978-08-20

下部尿路の尿流動態研究 : V. Alpha adrenergic blockerによる神経因性膀胱機能障害の治療

スポンサーリンク

概要

著者

関連論文

スポンサーリンク