Effects of Synthetic Hydroxy Isothiocyanates on Microbial Systems

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概要

• 論文の詳細を見る

• Hydroxy isothiocyanates (ITCs), including some new derivatives of naturally occurring compounds, were synthesized and their minimum inhibitory, minimum fungicidal, and minimum bactericidal concentrations for Aspergillus niger, Aspergillus fumigatus, Staphylococcus aureus, and Escherichia coli were estimated.These compounds were strongly antimicrobial;for example, 2-(4-hydroxyphenyl) ethyl ITC inhibited growth of all strains examined at concentrations of 7.8 to 15.6 μg/ml.The ATP concentration in E.coli was markedly reduced when cells were treated with 2-(4-hydroxyphenyl)ethyl ITC.Inhibition of the growth of E.coli by 2-(4-hydroxyphenyl)ethyl ITC was decreased in the presence of cysteine.Streptolysin S production in washed cells of Streptococcus equisimilis was extremely sensitive to this ITC derivative and this inhibition also was counteracted by cysteine.The results showed that the ITC compounds had antimicrobial effects by blocking sulfhydryl groups.

• 社団法人日本農芸化学会の論文
• 1998-03-23

著者

• Kimoto Hisashi

  Department Of Biochemistry I Fukui Medical School

• Kimoto Hisashi

  Department Of Applied Physics And Chemistry Fukui Institute Of Technology

• Kimoto Hisashi

  Department Of Biochemistry I Faculty Of Medicine Fukui Medical School

• Taketo A

  Department Of Applied Physics And Chemistry Fukui University Of Technology

• Taketo Akira

  Department Of Applied Physice And Chemistry

• TAJIMA Hirokuni

  Fukui Research Laboratory, Rengo Co., Ltd.

• TAKETO Yoriko

  Department of Pharmacology, Kanazawa University School of Medicine

• Taketo Yoriko

  Department Of Pharmacology Kanazawa University School Of Medicine

• Tajima Hirokuni

  Fukui Research Laboratory Rengo Co. Ltd.

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