Effect of Synthetic Hydroxy Isothiocyanates on a Bacterial Virus and DNA
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概要
- 論文の詳細を見る
The Effect of hydroxy isothiocyanates on a bacterial virus and M13 DNA was examined. Hydroxy-substituted phenyl and phenyl alkyl isothiocyanates, especially 2-(3,4-dihydroxyphenyl)ethyl isothiocyanate(IT-Dop) synthesized from dopamine, showed antiviral activity on φK. In transfection experiments with M13 mp DNA species, IT-Dop inhibited the single-stranded (SS) molecule more effectively than the double stranded replicative form (RF) DNA. These effects were dependent on reaction time, and on IT-Dop concentration. An additional experiment indicated that treatment with IT-Dop suppressed annealing (reassociation) of denatured DNA. These results indicate that IT-Dop reacts mildly with virus and SS DNA.
- 日本農芸化学会 = Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文
- 2007-04-23
著者
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Taketo Akira
Department Of Applied Physice And Chemistry
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Taketo Akira
Department Of Applied Physics And Chemistry Fukui University Of Technology
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Nakamoto Yoshiaki
Division Of Material Engineering Graduate School Of Natural Science And Technology Kanazawa Universi
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Nakamoto Yoshiaki
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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TAJIMA Hirokuni
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa Universit
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Tajima Hirokuni
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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