Formation of Thioxopyrrolidines and Dithiocarbamates from 4-Methylthio-3-butenyl Isothiocyanates, the Pungent Principle of Radish, in Aqueous Media
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概要
- 論文の詳細を見る
Reaction products of 4-methylthio-3-butenyl isothiocyanate (MTBI), the radish pungent principle, in aqueous media were identified and their antimicrobial activities were examined. A rapid degradation of MTBI in aqueous media afforded a mixture of 3-(hydroxy) methylene-2-thioxopyrrolidine (1), (Z)-3-(methylthio)-methylene-2-thioxopyrrolidine (2), its (E-isomer (3), methyl 4-methylthiobutyldithiocarbamate (4), methyl (Z)-4-methylthio-3-butenyldithiocarbamate (5), and its (E)-isomer (6). The products 1, 2, and 3 were detected at all pHs examined, while 4, 5, and 6 were formed at pH over 6.0. The formation of 4 from 6 was accompanied by an oxidation of methanethiol released from MTBI in aqueous media. Antimicrobial activities of 2 and 3 against all microbes examined were much lower than that of 1, which had MICs ranging from 50 to 400μg/ml. As for 4, 5, and 6, antifungal activities were comparable to that of 1, but little antibacterial activities were observed. The antimicrobial activities of the six products were considered to be far lower than that of MTBI.
- 社団法人日本農芸化学会の論文
- 1997-12-23
著者
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YONEYAMA Koichi
Weed Sci. Center, Utsunomiya Univ
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Matsuoka H
Department Of Health And Nutrition Takasaki University Of Health And Welfare
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Yoneyama Koichi
Weed Sci. Center Utsunomiya Univ.
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Yoneyama Koichi
Weed Science Center Utsunomiya University
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Yoneyama Kouichi
Department Of Obstetrics And Gynecology Nippon Medical School
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Uda Yasushi
Department Of Bioproductive Sciences Faculty Of Agriculture Utsunomiya University
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Uda Y
Niigata Coll. Niigata Jpn
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TAKAHASHI Asaka
Nagano Prefectural College
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MATSUOKA Hiroki
Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University
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TODA Yoshinori
Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University
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YANAGI Kenji
Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University
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TAKAHASHI Asaka
Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University
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UDA Yasushi
Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University
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Toda Yoshinori
Laboratory Of Food Chemistry Department Of Bioproductive Sciences Utsunomiya University
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YONEYAMA Koichi
Weed Control Research Institute, Faculty of Agriculture, Utsunomiya University
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