Antimicrobial Action of 2-Thioxo-3-pyrrolidinecarbaldehyde, a Major Thiolactam Compound Generated from the Pungent Principle of Radish in an Aqueous Medium.

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概要

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• 2-Thioxo-3-pyrrolidinecarbaldehyde (TPC), a major product generated from the pungent principle of radish in an aqueous medium was studied to characterize the mode of antimicrobial action. The minimum inhibitory concentration (MIC) of TPC was measured using 25 strains of microbes. The MICs against fungi and bacteria ranged from 50 to 400 μg/ml, while yeasts were more resistant. The effects of TPC on the growth of spores and mycelia of <I>Eurotium chevalieri</I> and on the survival of <I>Staphylococcus epidermidis</I> were investigated, which suggested that the antifungal and antibacterial actions were due to the sporicidal and bactericidal activities. Also, the effects of TPC on uptake of oxygen and radioactive precursors for RNA, DNA, proteins, peptideglycans, and lipids were examined in <I>S. epidermidis</I>. A dose-dependent inhibition of the uptakes of both oxygen and the precursors was observed, suggesting that TPC caused damage to the mitochondrial functions and biosynthetic systems of the biological materials.

• 社団法人 日本食品科学工学会の論文

著者

• MATSUOKA Hiroki

  Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University

• YANAGI Kenji

  Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University

• TAKAHASHI Asaka

  Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University

• UDA Yasushi

  Laboratory of Food Chemistry, Department of Bioproductive Sciences, Utsunomiya University

• MATSUOKA Hiroki

  Laboratory of Food Chemistry, Faculty of Agriculture, Utsunomiya University

• YANAGI Kenji

  Laboratory of Food Chemistry, Faculty of Agriculture, Utsunomiya University

• TAKAHASHI Asaka

  Laboratory of Food Hygiene, Nagano Prefectural Junior College

関連論文

• Formation of Thioxopyrrolidines and Dithiocarbamates from 4-Methylthio-3-butenyl Isothiocyanates, the Pungent Principle of Radish, in Aqueous Media
• Antimicrobial Action of 2-Thioxo-3-pyrrolidinecarbaldehyde, a Major Thiolactam Compound Generated from the Pungent Principle of Radish in an Aqueous Medium.

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