Enzymatic Synthesis of Novel Phosphatidylgenipin, and Its Enhanced Cytotoxity
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概要
- 論文の詳細を見る
A new phosphatidyl derivative, 1, 2-dipalmitoyl-3-sn-phosphatidylgenipin (DPP-genipin), was found to be synthesized by the transfer reaction of a dipalmitoylphosphatidyl residue from 1, 2-dipalmitoyl-3-sn-phosphatidylcholine (DPPC) to genipin by phospholipase D (PLD) from Streptomyces sp. in a biphasic system. DPP-genipin also transferred its phosphatidyl residue to choline by PLD, to reproduce DPPC and liberate genipin. DPP-genipin showed 6 to 52 times stronger cytotoxity than genipin to Hela cells, human embryonic lung fibroblasts (HEL), and MT-4cells.
- 社団法人日本農芸化学会の論文
- 1994-10-23
著者
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SUZUKI Yukio
Research Institute for Bioresources, Okayama University
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TAKAMI Masaaki
Central Research Laboratories, Kuraray Co., Ltd.
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Takami Masaaki
Centralresearch Laboratories Kuraray Co. Ltd.
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Suzuki Yukio
Research Institute For Bioresources Okayama University
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Suzuki Yukio
Research Lnstitute For Bioresources Okayama University
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Suzuki Yukio
Research Insititute For Bioresources Okayama University
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