RESPONSE OF POST-ISCHEMIC MYOCARDIUM TO SYMPATHETIC STIMULATION : Relation to Local Norepinephrine Release
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概要
- 論文の詳細を見る
Myocardial ischemia interrupts neurotransmission and causes the depression of norepinephrine release. However, the effects of sympathetic nerve stimulation on neurotransmission and norepinephrine release in post-ischemic myocardium are not well defined. We measured regional myocardial length and nor-epinephrine (NE) release during sympathetic nerve stimulation in anesthetized dogs. Dogs were divided into 2 groups: Group I (n=14); sympathetic nerve stimulation, Group 2 (n=9); pre-treatment with α-blockade yohimbine hydrochloride (0.2 mg/kg) followed by sympathetic nerve stimulation. The left anterior descending artery was occluded for 15 min. Sympathetic nerve stimulation was performed before coronary occlusion and after reperfusion. In group 1, the decrease in systolic shortening in the ischemic region persisted for more than 60 min. Although sympathetic nerve stimulation caused an increase in systolic shortening, it was lower than the pre-ischemic value. NE release from the post-ischemic myocardium remained decreased for 60 min. The decrease in the post-ischemic myocardial response to sympathetic nerve stimulation was associated with diminished NE release. When the cardiac sympathetic nerve was denervated with an epicardial phenol application, NE release decreased even further. In group 2, NE release did not decrease following reperfusion. These results suggest that sympathetic nerve conduction is not completely impaired in post-ischemic myocardium and that pre-synaptic a -2 receptors might play an important role in diminished NE release.
- 社団法人日本循環器学会の論文
- 1993-09-20
著者
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TAKAHASHI Keiji
Department of Respiratory Medicine, Kanazawa Medical University
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Miyazawa Kozui
Department Of Laboratory Medicine Yamagata University School Of Medicine
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Miyazawa Kozui
Department Of Biochemistry Yamagata University School Of Medicine
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Fukuyama Haru
Department of Clinical Laboratory, Yamagata University School of Medicine
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Komatsu Eiichi
Department of Clinical Laboratory, Yamagata University School of Medicine
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YAMAGUCHI ICHIRO
Department of Clinical Laboratory, Yamagata University School of Medicine
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Fukuyama Haru
Department Of Laboratory Medicine Yamagata University School Of Medicine
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Komatsu Eiichi
Department Of Laboratory Medicine Yamagata University School Of Medicine
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Komatsu Eiichi
Department Of Clinical Laboratory Yamagata University School Of Medicine
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Yamaguchi Ichiro
Department Of Laboratory Medicine Yamagata University School Of Medicine
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TAKAHASHI Keiji
the Department of Laboratory Medicine, Yamagata University School of Medicine
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Miyazawa Kozui
The First Department Of Internal Medicine And Clinical Laboratory
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Yamaguchi Ichiro
Department Of Clinical Laboratory Yamagata University School Of Medicine
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Fukuyama Haru
Department Of Clinical Laboratory Yamagata University School Of Medicine
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Takahashi Keiji
Department Of Laboratory Medicine Yamagata University School Of Medicine
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Takahashi Keiji
Department Of Chemical Engineering Faculty Of Engineering Fukuoka University
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Takahashi Keiji
The Department Of Laboratory Medicine Yamagata University School Of Medicine
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Miyazawa Kozui
Department of Laboratory Medicine, Yamagata University School of Medicine
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