Five-Year Intra-Individual Variability in C-Reactive Protein Levels in a Japanese Population-Based Study : The Jichi Medical School Cohort Study at Yamato, 1993-1998
スポンサーリンク
概要
- 論文の詳細を見る
C-reactive protein(CRP) is an acute-phase reactant that is related to future cardiovascular events. However, little is known about the long-term intra-individual stability of CRP in community residents. The 5-year intra-individual correlation of CRP levels was examined in the Jichi Medical School Cohort Study in Japan. CRP measurements were obtained in 1993 and in 1998 from 388 presumptively healthy individuals aged 30-69 years at baseline. The Pearson's correlation coefficient of CRP between baseline and follow-up measurements was 0.43 (95% confidence interval(CI): 0.34-0.51). Additional analyses by sex and smoking status at baseline revealed similar coefficients. The correlation coefficient of CRP was lower than that of other classical risk factors, such as body-mass index(BMI), blood pressure, and total and high-density lipoprotein(HDL) cholesterol. A subgroup of individuals with higher levels of CRP at both baseline and follow-up measurements had higher BMI, hemoglobin A1c, and plasma fibrinogen, and lower levels of HDL-cholesterol than others, even after adjusting for age, sex, and smoking status in a multiple logistic model. In conclusion, the stability of CRP levels was statistically significant in a long-term population-based study. A subgroup with higher levels of CRP who had an aggregation of cardiovascular risk factors was identified by the 2 measurements.
- 社団法人日本循環器学会の論文
- 2000-03-20
著者
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Gotoh Tadao
Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University
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Gotoh Tadao
自治医科大学地域医療学センター 地域医療学部門
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Gotoh Tadao
自治医科大学 公衆衛生学
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Nakamura Yosikazu
自治医科大学地域医療学センター 地域医療学
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Nakamura Yosikazu
千代田区千代田保健所
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Kayaba Kazunori
Department Of Cardiology And Internal Medicine Jichi Medical School
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Ishikawa Shizukiyo
自治医科大学 医学部循環器内科学
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Ishikawa Shizukiyo
Departement of Cardiology, Jichi Medical University School of Medicine
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GOTOH Tadao
Department of Internal Medicine, Wara National Health Insurance Hospital
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Nagao Naoki
Departments of Community and Family Medicine
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Kajii Eiji
Public Health Jichi Medical School
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Nakamura Yosikazu
Cardiology, Jichi Medical School
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Kario Kazuomi
See Appendix
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Jichi Medical
Jichi Medical School Cohort Study Group
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Nakamura Yosikazu
Division Of Epidemiology Miyagi Cancer Center Research Institute
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Nago Naoki
Community Medicine Education Center Japan Association For Development Of Community Medicine
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Goto Tadao
Kokuho Wara Hospital
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Niwa Yoshimitsu
自治医科大学 公衆衛生学
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Kajii Eiji
Division Of Community And Family Medicine Jichi Medical University
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