気管支喘息発症機序に関する研究 : 第1報.皮膚感作抗体と気道の過敏性よりの検討.

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House dust is a common causative antigen in atopic diseases, but some subjects demonstrate strongly positive skin reaction to house dust extract, yet with no apparent allergic symptoms. Why they are asymptomatic, and why some subjects develop only allergic r-hinitis but not bronchial asthma are still puzzling problem. In an attempt to study this, twelve subjects with strong cutaneous reaction to house dust antigen were selected from 360 normal subjects. Previous and family history were obtained, and determination of end point of intracutaneous skin test, eye test, titer of skin sensitizing antibody by P-K test, blocking antibody, inhalative provocation test with house dust extract and acetylcholine inhalation test were carried out. The results were compared with ten normal subjects with negative skin test and six asthmatic subjects with positive inhalative provocation test with house dust extract. The titer of skin sensitizing antibody and the end point of skin reactivity in asymptomatic subjects were as high as in asthmatic subjects but blocking antibody was not demonstrated. Inhalative provocation test was negative with house dust extract in all asymptomatic subjects and their air way trach were insensitive to acetylcholine as normal subjects. On the other hand, all asthmatic subjects were very sensitive to acetyllcholine and became more sensitive after intravenous injection of β-adrenergic blockade. In some cases, asthmatic attack was induced after intravenous injection of β-adrenergic blockade. All twelve asymptomatic subjects were not so effected with β-adrenergic blockade, however. From the result of our studies, it was thought that one of the reasons why they do not develop bronchial asthma even with high titer of skin sensitizing antibody is probably due to the less reactivity of the respiratory tract.
日本アレルギー学会の論文
1968-02-28

気管支喘息発症機序に関する研究 : 第1報.皮膚感作抗体と気道の過敏性よりの検討.

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