気管支喘息発症機序に関する研究 : 第2報 β-adrenergic blocking agent を用いての検討

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2. From the investigation with beta-adrenergic blocking agent. Some believed that the constitutional abnormality common to all atopics, especially asthmatics, is inherited of acquired partial blockade (reduced functioning or availability) of the beta-adrenergic receptor. Others stated, however, that partial blockade of the beta-adrenergic receptors is not as important in asthmatics as believed. To assess their points, 17 asthmatic patients, 10 normal subjects and 11 asymptomatic subjects with skin sensitizing antibody were studied. After intravenous injection of propranolol, 6 out of 17 asthmatic patients developed asthmatic attack, and other 4 showed more than 10% reduction of FEV_1, but no significant changes of FEV_1 was noted in normal and asymptomatic subjects. Bronchial sensitivity to aerosolized aceptylcholine increased after injection of propranolol in normal and asymptomatic subjects but their sensitivity did not reach to the range of asthmatic patients. Inhalation provocation test was carried out in 11 asymtomatic subjects before and after propranolol injection but none showed positive even with the presence of skin sensitizing antibody. On the other hand, provocation test became positive in some cases of bronchial asthma after intravenous injection of propranolol. Consequently it is our feeling that the blockade of the beta-adrenegic receptor is not essential but makes subjects predisposed to asthmatic condition. Pliability of respiratory tract might be more important in asthma, however.
日本アレルギー学会の論文
1968-07-31

気管支喘息発症機序に関する研究 : 第2報 β-adrenergic blocking agent を用いての検討

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