気管支喘息及び前段階における2, 3の免疫学的考察

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For the proper understanding of the mechanism of development of bronchial asthma it is mandatory to follow its course from the very beginning. Following 53 cases in the presathmatic stage for 3 years the authors noted 22% of them developed bronchial asthma. The following laboratory studies were performed to investigate the characteristics of bronchial asthma and preasthmatic stage. 1) Studies of the total serum protein and its analysis revealed theα_2 globulin in asthmatic children was somewhat higher than that of the control group. 2) Immunoglobulin was determined quantitatively with an immunoplate. Asthmatic children were noted to have elevated × A as compated with the control group, whereas inγG and γM no significant difference was noted between the asthmatic and the control group. 3) The metabolism of γG globulin was investigated. ^<131>I labeled γG globulin turnover studies demonstrated that in asthmatic children the intravascular percentage of γG was lower than in the control group and its half life was prolonged. Accordingly, the turn-over rate, absolute catabolic, synthetic and degradation rate were also significantly low. 4) After the injection of blood group A and B substances, no significant differences between the asthmatic group and the control group were noted in the titer of isohemagglutinin. 5) Serum histamino-pexic action was determined in asthmtic and preasthmatic stage children. Histaminopexy in asthmatic and preasthmatic children were significantly lower than in the control group. Besides, they were hypersensitive to nasal provocation test of histamine. 6) There was a significant difference between asthmatic and preasthmatic children and the control group in the response of the shock organ to methacholine inhalation test.
日本アレルギー学会の論文
1967-03-30

気管支喘息及び前段階における2, 3の免疫学的考察

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