アレルギー性小児の血清免疫グロブリン量並びに抗体産生能に関する研究

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For the proper understanding of the mechanism of antibody formation in the immune apparatus of atopic individuals, it is suggested that quantitative immunoglobulin levels and antibody response are very inportant. So, the present study was undertaken to clarify the mechanism of antibody formation by the following three methods. 1. Total serum protein and electrophoretic analyses of serum protein. There was no difference in the protein values between the normal and the asthmatic children. Electrophoretic analyses of serum protein revealed α-globulin and α_2globulin in the asthmatic children were somewhat higher than those in the control group. 2. Quantitative IgG, IgAand gIM determinations. Immunoglobulins were determined quantitatively with an immunoplate. A statistically significant elevation of IgA was sene in the asthmatic group, whereas in the case of IgG and IgM, no significant difference was noted between the asthmatic and the control group. 3. Antibody response. The allergic children were given inactivated measles virus vaccine and live attenuated measles vaccine at monthly inteval. Measles neutralizing antibody titers of allergic children were significantly lower than those of the control children. Besides, asthmatic chidlren were given inactivated japanese. B. encephalitis virus vaccine. The virus hemagglutination inhibition antibody titers of these children were also lower than those of the control children. Therefore, the data suggest that the antibody response to the virus in allergic children might be suppressed.
日本アレルギー学会の論文
1969-04-30

アレルギー性小児の血清免疫グロブリン量並びに抗体産生能に関する研究

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