気管支喘息の減感作ならびに燐酸クロロキン剤併用療法について

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One hundred and thirty-three patients with bronchial asthma were studied to detect their allergen by skin test and among them sixty-two patients were given a specific hyposensetization treatment combined with the administration of chlorquine phosphate. The results obtained were as follows. 1) The frequency of positive reaction of skin test to antigen extracts was higher in asthmatic patients than in healthy persons. Out of seventy-six asthmatic patients, who were examined with more than twenty antigen extracts, sixty-three cases (82.9%) showed positive reaction to one or more of these antigens. Frequencies of positive skin test with such antigen extract as house dust, pollen of pine, pork, gingko nut, milk and buckwheat flour were especially higher than those with other antigen extracts. As to the extract of sea-squency of positive skin test was extremly high in asthmatics of "Kakiuchiko", who were engaged in cracking the oyster by a hook to take out its flesh, while it was low in "Kakiuchiko" without asthma or in asthmatics without this particular occupation, "Kakiuchiko" or "Cracking the Oyster". 2) Asthmatic patients, whose paroxysms had continued all the year round, usually showed a pasitive positivr skin reaction to many sorts of antigen extracts at the same time and especially many of them revealed a positive skin reaction to house dust. However in patients, whose pasoxysms were apt to appear in the cold season, a small number of antigen extracts produced a positive skin reaction. 3) Out of sixty-two patients, who were given a specific hyposensitization treatment combined with the administration of chloroquine phosphate for one to sixteen months, results were excellent in thirty-six cases, favourable in twenty-two cases and ineffective in four cases, namely the therapy was proved to be effective in 93.5% of the patients. The effectiveness of this combined therapy became more remarkable as the patients recieved the therapy for longer duration. There were no relationships, however, between the effectiveness of the therapy and both the grade or duration of the disease and age of patients. 4) During this combined therapy vital capacity, maximal breathing capacity and air verocity index increased and oxygen quotient became normal in almost all patients. 5) Some slight side effects were seen during the treatment, but there was no trouble to continue the therapy.
日本アレルギー学会の論文
1963-09-30

気管支喘息の減感作ならびに燐酸クロロキン剤併用療法について

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