The Effects of Tritiated Water on the Bone Marrow Cells in Mice

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The acute effects on hematopoietic tissue in mice of a single administration of tritiated water were compared with the effects of exposure to ^<60>Co gamma radiation. The activity of tritium in the bone marrow was measured directly using a sample oxidizer and the absorbed dose was calculated from the amount of activity of tritium in it. The number of nucleated cells, colony forming unit-spleen (CFUs), colony forming unit-culture (CFUc), and fibroblastoid colony forming unit (CFUf) in bone marrow were determined to evaluate the effects of tritium and ^<60>Co gamma radiation on bone marrow. The dose-response curves were derived from the observed data and the RBE values of tritium beta rays relative to ^<60>Co gamma rays were calculated to be 0.91, 1.09 and 1.51 for nucleated bone marrow cells, CFUs and CFUc, respectively, for 2 days exposure to HTO and ^<60>Co gamma radiation.
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