Cell-Mediated Immunity in Host after Tumor Irradiation1
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概要
- 論文の詳細を見る
The immunological activity of the host after tumor irradiation was investigated in in vivo and in vitro system. The spleen cells from tumor irradiated mice inhibited growth of tumor in mice which were inoculated tumor cells together with these spleen cells. These spleen cells also inhibited the colony formation, and tumor growth in in vitro system. The cytostatic activity of spleen cells against tumor cells was enhanced after local tumor irradiation. It was also shown that enhancement of specific anti-tumor cell-mediated immunity of spleen cells in host occurred 7 or more days following local irradiation to tumor and continued for several weeks. The effect of tumor radiotherapy is generally considered to be due to the tumor cell killing effect of radiation. However, progress in tumor immunology shows that the immunological activity of the host also has some effect on the tumor and plays important role in the prognosis after radiotherapy.
- 日本放射線影響学会の論文
著者
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Norimura Toshiyuki
Department Of Radiation Biology And Health School Of Medicine University Of Occupational And Environ
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Okamoto Mieko
Department Of Biochemistry The Tokyo Metropolitan Institute Of Medical Sciences
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Norimura Toshiyuki
Department Of Radiation Biology And Health University Of Occupational And Environmental Health
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Tsuchiya Takehiko
Department Of Obstetrics And Gynecology Toho University Omori Medical Center
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Tsuchiya Takehiko
Department Of Radiation Biology And Health University Of Occupational And Environmental Health
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