Intestinal Tumorigenesis in Min Mice is Enhanced by X-irradiation in an Age-dependent Manner
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概要
- 論文の詳細を見る
We examined the effect of X-irradiation on intestinal tumorigenesis in Min (multiple intestinal neoplasia) mice. Single whole-body irradiation was given to mice of various ages from newborn to young adults. On the C57BL/6J (B6) background, X-irradiation increased tumor multiplicity of the small intestine exposed at ages from 2-3 days to 24-25 days, with a peak of 2.7-fold increase at 10-12 days of age; exposure at later ages resulted in only a slight increase. X-irradiation also increased colonic tumors; however, the susceptible age period appeared earlier than that of the small intestine; the peak value of 4.6-fold increase was observed in the exposure at around 2-3 days of age. Irradiation at 24 days or later ages showed almost no effect on the colonic tumor induction. On the (B6 x MSM)F_1 background, X-irradiation resulted in 2.7-fold increase in the small intestinal tumors, but no increase in the colonic tumors, and besides, the age dependency observed in the small intestinal tumors was much attenuated. Collectively, we conclude that tumorigenic efficacy of X-irradiation in Min mice was determined by the combination of the target organ, the age at exposure, and the genetic background.
- 日本放射線影響学会の論文
- 2005-03-25
著者
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YONEKAWA Hiromichi
Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science
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Yonekawa Hiromichi
Department Of Laboratory Animal Science Tokyo Metropolitan Institute Of Medical Science Tokyo Metrop
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OKAMOTO Mieko
Department of Laboratory Animal Science, Tokyo Metropolitan Institute of Medical Science Tokyo Metro
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Okamoto Mieko
Department Of Laboratory Animal Science Tokyo Metropolitan Institute Of Medical Science Tokyo Metrop
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Okamoto Mieko
Department Of Biochemistry The Tokyo Metropolitan Institute Of Medical Sciences
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Yonekawa Hiromichi
Department Of Animal Science The Tokyo Metropolitan Institute Of Medical Science
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