Structure of Mouse Interferon Stimulated Gene Factor 3.GAMMA. (ISGF3.GAMMA./p48) cDNA and Chromosomal Localization of the Gene.
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概要
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Interferon stimulated gene factor 3 (ISGF3) is a trimeric transcription factor activated on treatment of cells with interferon-α and β (type I IFNs). Upon stimulation, the regulatory subunits, p84/91 and p113, present in the cytoplasm are phosphorylated at specific tyrosine residues and assemble with the DNA binding subunit, ISGF3γ, into the active ISGF3 in the nucleus. Thus, ISGF3 plays a primary role in the transmission of a signal from the cell surface to the nucleus. In this report, we describe the cloning of a mouse eDNA encoding a polypeptide homologous to human ISGF3γ. Comparison of the deduced amino acid sequences revealed the middle region was significantly different between mouse and man. The mouse cDNA was shown to encode a functional ISGF3 subunit by means of an in vitro reconstitution assay. Furthermore, the locus of the ISGF3γ gene, designated as Isgf3g, was mapped to distal mouse chromosome 14 by linkage analysis using an intersubspecific backcross typing panel.
- 社団法人 日本生化学会の論文
著者
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Yonekawa Hiromichi
Department Of Animal Science The Tokyo Metropolitan Institute Of Medical Science
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Suhara Wakako
Department Of Tumor Cell Biology The Tokyo Metropolitan Institute Of Medical Science
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Yoneyama Mitsutoshi
Department Of Tumor Cell Biology The Tokyo Metropolitan Institute Of Medical Science
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Fujita Takashi
Department Of Anesthesiology Suwa Red Cross Hospital
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