CaO-B_2O_3-SiO_2系ガラスの生体活性の組成依存性: in vitro評価(<特集>セラミックスの合成と評価)

概要

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The essential condition for glasses and glass-ceramics to bond to living bone is the formation of a biologically active bone-like apatite layer on their surfaces in the body. In the present study, in order to investigate fundamentally the effect of B_2O_3 on the bioactivity of glasses and glass-ceramics, the compositional dependence of apatite formation on the surface of glasses in the system CaO-B_2O_3-SiO_2 was examined in the simulated body fluid. Substitution of small amounts of B_2O_3 for SiO_2 in CaO・SiO_2 formula increased the rate of apatite formation on the surface of the glass, while substitution of more than 30 mo1% B_2O_3 for SiO_2 decreased it. The substitution of B_2O_3 for SiO_2 in CaO-SiO_2 binary glasses accelerated the dissolution of Ca(II) ion from the glasses, and hence enhanced the increasing rate of degree of supersaturation of the surrounding fluid with respect to apatite. The decrease in the apatite forming ability by substitution of large amounts of B_2O_3 for SiO_2 is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.
社団法人日本材料学会の論文
1995-06-15