ゾル-ゲル法によるカルシウムイオンのゼラチン-シロキサンハイブリッドへの導入

概要

論文の詳細を見る
Several gelatin-siloxane hybrids incorporating Ca^<2+> ions were synthesized through a sol-gel process starting with gelatin, 3-(glycidoxypropyl) trimethoxysilane (GPSM), and Ca(NO_3)_2. Amino acid analysis, ^<29>Si NMR spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and dynamic mechanical thermal analysis were used to assess the hybrid structure. It has been indicated that the grafting degree of epoxy groups of GPSM to gelatin and the extent of polymerization of methoxysilane end groups of GPSM strongly depended on the fraction of GPSM (f_G) in the hybrids, but not on incorporation of Ca^<2+> ions. Hence, the hybrids with the same f_G value, independent of incorporation of Ca^<2+> ions, had a similar cross-link density. However, the glass transition temperature (T_g) and storage modulus (E') around T_g decreased with incorporation of Ca^<2+> ions. Through the deconvolution of amide I bands of FT-IR spectra, flexibility may be interpreted by that the percentage of gelatin having a random structure increased with incorporation of Ca^<2+> ions. The Ca^<2+>-containing hybrids can spontaneously deposit apatite when they were soaked in a simulated body fluid of the Kokubo recipe, showing their bioactivity.
社団法人日本セラミックス協会の論文
2001-05-01