A METHOD OF EARLY DETECTION OF OVARIAN CANCER BY CELL-MEDIATED IMMUNOLOGIC TECHNIQUES

概要

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The extreme difficulty in early detection of ovarian cancer enticed the present authors to develop a cell-mediated immunologic method. This method used two indices, namely, the lymphocyte response per unit volume of peripheral blood to phytohemagglutinin (PHA) and the immuno-suppressive effect of serum on the response of normal lymphocytes to PHA stimulation. The lymphocyte response per 50 μl peripheral blood did not differ significantly between patients with ovarian cancer and healthy volunteers. The serum effect, in contrast, differed significantly between malignant and benign ovarian tumors, and was found to increase significantly even when the cancer mass (es) was (were) goose egg size. The authors believe that the measurement of the serum immuno-suppressive effect in patients with any ovarian tumor enables the early detection of ovarian cancer.
社団法人日本産科婦人科学会の論文
1977-11-01