鎖肛に関する基礎的研究 : III.ブタ鎖肛の遺伝性に関する検討

概要

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Large portion of anorectal anomalies in swine was believed to be hereditary in the literature. In our series of experiments on the defect in swine, we have completed a radical operation technique in neonatal age and then performed deliberate matings among grown-up male and femal pigs with the corrected anomalies. Sixty-four pigs with defect were included in this study : 35 were males and 29 were females. We could analyze the heredity of this anomaly mainly in 3 swine families. Among 18 deliveries after mating, we could observe anorectal in 9 deliveries. The existence of heredity has been ensured. The hereditary trait was studied, mainly on 3 pig families. In K Farm family, the autosomal recessive genes were indicated. In Y Farm family, the autosomal dominant genes were indicated. Particularly, the mating between a male impeforate anus and a normal female sibling resulted to give 2 males with imperforate anus of high type and 9 females with rectovestibular fistula. The total occurence of the defect in this delivery is supported to be due both to dominant genes from grand father and recessive genes from grand mother. In the I Farm family, the autosomal reccssive genes were suggested by the analysis on 6 generations of this pig family tree. The genes to cause the defect were concluded to be common between male and female, as far as our experiments were concerned.
日本小児外科学会の論文
1986-05-20